Earlier known as the Harwood Plantation, the house was built in 1769 by William Harwood along the Great Warwick Road, which linked the colonial capital of Williamsburg with the town of Hampton on the harbor of Hampton Roads. The 238-year-old house and grounds were used by military forces during the Revolutionary War. General Thomas Nelson, Jr.'s Virginia Militia used it as a resting place on September 28, 1781, en route to Yorktown  shortly before the surrender of the British troops under Lord Cornwallis.
Military use again came during the War of 1812 and the American Civil War. Then the home of Dr. Humphrey Harwood Curtis, Jr., one of two doctors in Warwick County, Virginia, Endview also served as a hospital during the 1862 Peninsula Campaign of the Civil War.
Endview was acquired by the City of Newport News in 1995. Endview Plantation is the home of "The Civil War at Endview: A Living History Museum". The property has been used for military reenactments including events related to the 225th anniversary of the Siege of Yorktown which was held in 2006. As of Summer 2010, operating hours have been cut back so that the site is closed to the public Tuesday and Wednesday.