Lang Syne Plantation is a historic plantation near St. Matthews, Calhoun County, South Carolina. The plantation was established in the 18th century by Ann Heatly Reid Lovell and her nephew Langdon Cheves, a prominent South Carolina politician and president of the Second Bank of the United States.

The present Classical Revival plantation house was built in 1901. Julia Peterkin lived there with her planter husband and based many of her novels on the Gullah people of the Low Country.