Iberville Parish records show that Tally Ho was owned by Jean Fleming, a free man of color, sometime before 1855. There were several more owners after Fleming. John Dobbins Murrell of Virginia bought the plantation in 1848, and it has remained in the family ever since. The home is said to have been moved back from the Mississippi River twice and the main house burned in 1945. The name Tally Ho is said to reflect Murrell's fox-hunting background. The current house is what was used as the overseer's home. It is a raised Acadian cottage with Classical Revival influences.

The plantation's river dock was the site of showboat performances. The New Sensations, the first of the Mississippi River troubadours, stopped there in 1878 to perform a vaudeville-type show. The barn, office and a slave cabin remain down a side road.