Appomattox Manor is a former plantation house in Hopewell, Virginia, United States. It is best known as the Union headquarters during the Siege of Petersburg in 1864-65.

The restored circa 1751 manor house on a bluff overlooking the confluence of the James River and Appomattox River, and the grounds are managed by the National Park Service. The museum there, Grant's Headquarters at City Point Museum, is a unit of the Petersburg National Battlefield Park.